CIP2A inhibitor TD52

Chemical Structure : CIP2A inhibitor TD52

CAS No.: 1798328-24-1

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货号: PC-23570Not For Human Use, Lab Use Only.

TD52 is a small molecule inhibitor of cancerous inhibitor of protein phosphatase 2A (CIP2A), downregulates CIP2A and p-Akt, reactivates protein phosphatase 2A.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

TD52 is a small molecule inhibitor of cancerous inhibitor of protein phosphatase 2A (CIP2A), downregulates CIP2A and p-Akt, reactivates protein phosphatase 2A.
TD52 causes greater reduction in cell viability than erlotinib in all the HCC cell lines tested including HA22T (IC50=0.9 μmol/l), Hep3B (IC50=0.9 μmol/l), PLC5 (IC50=0.8 μmol/l) and Sk-Hep1 (IC50=1.2 μmol/l), which is independent of EGFR kinase inhibition.
TD52 downregulates the protein expression of CIP2A and p-Akt in a dose- and time-dependent manner, with no effect on the expression level of PP2A-related subunits, PP2A-A, PP2A-B55 and PP2A-C.
TD52 downregulates transcription of CIP2A via interfering Elk-1 function.
TD52 (10 mg/kg/day) exhibits in vivo antitumor effects on a PLC5 xenograft tumor model.

物理化学性质&存储条件

分子量	360.42
分子式	C24H16N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N2,N3-Bis(3-ethynylphenyl)quinoxaline-2,3-diamine

参考文献

1. Yu HC, et al. Cell Death Dis. 2014 Jul 31;5(7):e1359.