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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Estrogen Receptor/ERR-CIDD-0149897
CIDD-0149897

Chemical Structure : CIDD-0149897

CAS No.: 2862784-20-9

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CIDD-0149897 (CIDD0149897)

货号: PC-21008Not For Human Use, Lab Use Only.

CIDD-0149897 is a potent, selective, brain permeable estrogen receptor beta (ERβ) agonist, 40-fold selective over ERα.

规格 价格 库存 数量
5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥4280 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CIDD-0149897 is a potent, selective, brain permeable estrogen receptor beta (ERβ) agonist, 40-fold selective over ERα.
CIDD-0149897 markedly reduced GBM cell viability with an IC50 of ~7-15 µM, while having little to no effect on ERβ-KO cells and normal human astrocytes.
CIDD-0149897 enhanced expression of known ERβ target genes and promoted apoptosis in established and patient-derived GSC models.
CIDD-0149897 significantly decreased tumor growth in U251 xenograft model and extended the survival of orthotopic GBM tumor-bearing mice.

物理化学性质&存储条件

分子量 271.25
分子式 C15H10FNO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2Z)-6-(3-fluoro-4-hydroxyphenyl)-2-hydroxyimino-3H-inden-1-one

参考文献

1. Uday P Pratap, et al. Mol Cancer Ther. 2023 Jul 26;MCT-23-0031.

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