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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MNK-CID661578
CID661578

Chemical Structure : CID661578

CAS No.: 1164547-89-0

CID661578 (CID 661578)

货号: PC-38906Not For Human Use, Lab Use Only.

CID661578 is a potent inducer of β-cell regeneration, targets MAP kinase-interacting serine/threonine kinase 2 (MNK2).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CID661578 is a potent inducer of β-cell regeneration, targets MAP kinase-interacting serine/threonine kinase 2 (MNK2).
    CID661578 increased β-cell neogenesis from ductal cells in zebrafish, neonatal pig islet aggregates and human pancreatic ductal organoids.
    CID661578 boosts protein synthesis and regeneration by blocking MNK2 from binding eIF4G in the translation initiation complex at the mRNA cap.

    物理化学性质&存储条件

    分子量 356.353
    分子式 C19H17FN2O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    9-fluoro-N-(furan-2-ylmethyl)-3-hydroxy-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxamide

    参考文献

    1. Karampelias C, et al. Nat Chem Biol. 2022 Jun 13. doi: 10.1038/s41589-022-01047-x.

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