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首页-小分子抑制剂&激动剂-Others-Other Targets-CID 2745687
CID 2745687

Chemical Structure : CID 2745687

CAS No.: 264233-05-8

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CID 2745687 (CID-2745687)

货号: PC-38606Not For Human Use, Lab Use Only.

CID-2745687 is a potent, selective and competitive GPR35 antagonist with pIC50 of 6.7 against human GPR35.

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5 mg ￥1180 In stock
10 mg ￥1880 In stock
25 mg ￥3280 In stock
50 mg ￥5280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CID-2745687 is a potent, selective and competitive GPR35 antagonist with pIC50 of 6.7 against human GPR35.
CID-2745687 competitively inhibited the effects at human GPR35 of cromolyn disodium and zaprinast, two agonists that share an overlapping binding site.
CID-2745687 blocked zaprinast-promoted VSMC migration in the scratch-wound assay.

物理化学性质&存储条件

分子量 395.429
分子式 C17H19F2N5O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

methyl-5-[(tert-butylcarbamothioylhydrazinylidene)methyl]-1-(2,4-difluorophenyl)pyrazole-4-carboxylate

参考文献

1. Jenkins L, et al. J Pharmacol Exp Ther. 2012 Dec;343(3):683-95.

2. McCallum JE, et al. J Vasc Res. 2015;52(6):383-95.

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