CID16020046 | GPR55 antagonist | Probechem Biochemicals

Chemical Structure : CID16020046

CAS No.: 834903-43-4

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CID16020046 (CID 16020046)

货号: PC-45043Not For Human Use, Lab Use Only.

CID16020046 is a potent and selective GPR55 antagonist with IC50 of 0.15 uM.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

CID16020046 is a potent and selective GPR55 antagonist with IC50 of 0.15 uM.
CID16020046 significantly inhibits the LPI-induced ERK1/2 phosphorylation in HEK-GPR55 cells at 2.5 uM, concentration dependently inhibits LPI-induced activation of NFAT, NF-κB and serum response element, translocation of NFAT and NF-κB, and GPR55 internalization.
CID16020046 reduces LPI-induced wound healing in primary human lung microvascular endothelial cells and reverses LPI-inhibited platelet aggregation.

物理化学性质&存储条件

分子量	425.4361
分子式	C25H19N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 28 mg/mL
Chemical Name/SMILES	Benzoic acid, 4-[4,6-dihydro-4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxopyrrolo[3,4-c]pyrazol-5(1H)-yl]-

参考文献

1. Kargl J, et al. J Pharmacol Exp Ther. 2013 Jul;346(1):54-66.

2. Kargl J, et al. Br J Pharmacol. 2016 Jan;173(1):142-54.

3. Montecucco F, et al. Thromb Haemost. 2016 Oct 28;116(5):987-997.

CID16020046 (CID 16020046)

生物&药学活性

物理化学性质&存储条件

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CID16020046 (CID 16020046)

生物&药学活性

物理化学性质&存储条件

参考文献

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