CI-976 | ACAT-1 inhibitor | Probechem Biochemicals

Chemical Structure : CI-976

CAS No.: 114289-47-3

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CI-976 (PD 128042)

货号: PC-62403Not For Human Use, Lab Use Only.

CI-976 (PD 128042) is a potent, selective, orally bioavailable inhibitor of ACAT-1 (Acetyl-CoA acetyltransferase 1) with IC50 of 73 nM, also inhibits sterol O-acyltransferase 1 (SOAT1) with IC50 of 6.95 uM (hSOAT1).

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10 mg	￥1280	In stock
25 mg	￥2280	In stock
50 mg	￥3880	In stock
100 mg		Get quote

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生物&药学活性

CI-976 (PD 128042) is a potent, selective, orally bioavailable inhibitor of ACAT-1 (Acetyl-CoA acetyltransferase 1) with IC50 of 73 nM, also inhibits sterol O-acyltransferase 1 (SOAT1) with IC50 of 6.95 uM (hSOAT1).
CI-976 decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits.

物理化学性质&存储条件

分子量	393.568
分子式	C23H39NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-dodecanamide

参考文献

1. Field FJ, et al. Lipids. 1991 Jan;26(1):1-8.

2. O'Brien PM, et al. J Med Chem. 1994 Jun 10;37(12):1810-22.

3. Krause BR, et al. J Lipid Res. 1993 Feb;34(2):279-94.

4. Baba T, et al. Mol Cell Biochem. 2013 Apr;376(1-2):151-61.

CI-976 (PD 128042)

生物&药学活性

物理化学性质&存储条件

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CI-976 (PD 128042)

生物&药学活性

物理化学性质&存储条件

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