CHR6494 | Haspin inhibitor | Probechem Biochemicals

Chemical Structure : CHR6494

CAS No.: 1333377-65-3

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CHR6494 (CHR-6494)

货号: PC-49321Not For Human Use, Lab Use Only.

CHR-6494 (CHR6494) is a potent, selective inhibitor of the histone kinase Haspin with IC50 of 2 nM, shows anti-proliferative effects in human cancer cells.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2680	In stock
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生物&药学活性

CHR-6494 (CHR6494) is a potent, selective inhibitor of the histone kinase Haspin with IC50 of 2 nM, shows anti-proliferative effects in human cancer cells.
CHR-6494 displays selectivity over 27 other protein kinases including Aurora B kinase.
CHR-6494 inhibits cancer cell growth dose dependently with IC50 500 nM for HCT-116, 473 nM for HeLa and 752 nM for MDA-MB-231 cells.
CHR-6494 reduces H3T3ph levels in a dose-dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification.
CHR-6494 causes arrest in G2/M and subsequently apoptosis in cancer cells.
CHR-6494 demonstrates anti-angiogenetic features in ex vivo assays, shows antitumor potential in xenografted nude mice without any observed toxicity in vivo.

物理化学性质&存储条件

分子量	292.346
分子式	C16H16N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine

参考文献

1. Huertas D, et al. Oncogene. 2012 Mar 15;31(11):1408-18.

2. Han L, et al. J Cancer. 2017 Aug 25;8(15):2933-2943.

CHR6494 (CHR-6494)

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物理化学性质&存储条件

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CHR6494 (CHR-6494)

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