CHMFL-KIT-031

Chemical Structure : CHMFL-KIT-031

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货号: PC-62536Not For Human Use, Lab Use Only.

CHMFL-KIT-031 is a highly selective KIT kinase primary V559D mutant inhibitor with IC50/Kd of 28/266 nM, 10-20 fold selectivity over KIT wt.

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100 mg		Get quote

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生物&药学活性

CHMFL-KIT-031 is a highly selective KIT kinase primary V559D mutant inhibitor with IC50/Kd of 28/266 nM, 10-20 fold selectivity over KIT wt.
CHMFL-KIT-031 also displays 15-400-fold selectivity over other primary mutants such as L576P and secondary mutants including T670I, V654A as well as N822K and D816V.
CHMFL-KIT-031 exhibits a selectivity S score (1) of 0.01 among 468 kinases/mutants in the KINOMEScan™ assay.
CHMFL-KIT-031 inhibits the proliferation of BaF3-TEL-KIT-V559D cells with IC50 of 25 nM, shows potent inhibitory efficacy for KIT V559D mediated signaling pathways in cell and anti-tumor activity in vivo.

物理化学性质&存储条件

分子量	487.516
分子式	C26H25N5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3,4,5-trimethoxy-N-(2-oxo-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)ethyl)benzamide

参考文献

1. Yu K, et al. Oncotarget. 2017 Nov 15;8(67):111110-111118.

CHMFL-KIT-031

生物&药学活性

物理化学性质&存储条件

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CHMFL-KIT-031

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物理化学性质&存储条件

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