CHMFL-ABL-053 |CAS:1808287-83-3 Probechem Biochemicals

Chemical Structure : CHMFL-ABL-053

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CHMFL-ABL-053 (ABL-053)

货号: PC-63026Not For Human Use, Lab Use Only.

CHMFL-ABL-053 is a potent, selective and orally available Bcr-Abl/Src/p38 kinase inhibitor with IC50 of 70/62/90 nM.

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生物&药学活性

CHMFL-ABL-053 is a potent, selective and orally available Bcr-Abl/Src/p38 kinase inhibitor with IC50 of 70/62/90 nM.
CHMFL-ABL-053 shows no inhibitory activity against c-Kit (>10 uM).
CHMFL-ABL-053 inhibits the proliferation of CML cell lines K562 (GI50=14 nM), KU812 (GI50=25 nM), and MEG-01 (GI50=16 nM).
CHMFL-ABL-053 completely suppresses tumor progression in the K562 cells inoculated xenograft mouse model with 50 mg/kg/day dosage treatment.

物理化学性质&存储条件

分子量	549.558
分子式	C28H26F3N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3-Amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide

参考文献

1. Liang X, et al. J Med Chem. 2016 Mar 10;59(5):1984-2004.

CHMFL-ABL-053 (ABL-053)

生物&药学活性

物理化学性质&存储条件

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CHMFL-ABL-053 (ABL-053)

生物&药学活性

物理化学性质&存储条件

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