Laduviglusib (CHIR-99021, CT99021) | GSK-3 inhibitor | Probechem Biochemicals

Chemical Structure : CHIR-99021

CAS No.: 252917-06-9

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CHIR-99021 (Laduviglusib, CT99021, CHIR99021)

货号: PC-42428Not For Human Use, Lab Use Only.

Laduviglusib (CHIR-99021, CT99021) is a potent, specific GSK-3 inhibitor with IC50 of 5 nM and 10 nM for GSK3β and GSK3α, respectively.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3780	In stock
100 mg		Get quote

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生物&药学活性

Laduviglusib (CHIR-99021, CT99021) is a potent, specific GSK-3 inhibitor with IC50 of 5 nM and 10 nM for GSK3β and GSK3α, respectively.
Laduviglusib (CHIR-99021, CT99021) mimics Wnt signaling in preadipocytes, stabilizes free cytosolic beta-catenin and inhibits adipogenesis by blocking induction of C/EBPα and PPARγ.
Laduviglusib (CHIR-99021, CT99021) potentiates insulin activation of glucose transport and utilization in vitro and in vivo.
Laduviglusib (CHIR-99021, CT99021) is also widely used for stem cell differentiation and naive stem cell generation.

物理化学性质&存储条件

分子量	465.3379
分子式	C22H18Cl2N8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 5.1 mg/mL
Chemical Name/SMILES	3-Pyridinecarbonitrile, 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-

参考文献

1. Ying QL, et al. Nature. 2008 May 22;453(7194):519-23.

2. Ring DB, et al. Diabetes. 2003 Mar;52(3):588-95.

3. Bennett CN, et al. J Biol Chem. 2002 Aug 23;277(34):30998-1004.

4. Li W, et al. Stem Cells. 2009 Dec;27(12):2992-3000.

CHIR-99021 (Laduviglusib, CT99021, CHIR99021)

生物&药学活性

物理化学性质&存储条件

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CHIR-99021 (Laduviglusib, CT99021, CHIR99021)

生物&药学活性

物理化学性质&存储条件

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