CHIR-98014 | GSK-3 inhibitor | Probechem Biochemicals

Chemical Structure : CHIR-98014

CAS No.: 252935-94-7

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CHIR-98014 (CHIR98014, CHIR 98014)

货号: PC-43377Not For Human Use, Lab Use Only.

CHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

CHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively.
CHIR-98014 shows less potent activities against 20 other protein kinases including Cdc2 and Erk2; causes GS stimulation in CHO-IR cells and rat hepatocytes, with EC50s of 106 nM and 107 nM, respectively.
CHIR-98014 reduces the viability of ES-CCE cells with IC50 of 1.1 uM, results in a significant activation of the Wnt/beta-catenin pathway in ES-D3 cells combined with CHIR-99021.
CHIR-98014 significantly reduces fasting hyperglycemia within and shows improved glucose disposal in diabetic and insulin-resistant db/db mice.

物理化学性质&存储条件

分子量	486.3141
分子式	C20H17Cl2N9O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 11 mg/mL
Chemical Name/SMILES	2,6-Pyridinediamine, N6-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-

参考文献

1. Ring DB, et al. Diabetes. 2003 Mar;52(3):588-95.

2. Lian X, et al. Cell Reports. 2015 Jan 13;4(1):170.

CHIR-98014 (CHIR98014, CHIR 98014)

生物&药学活性

物理化学性质&存储条件

参考文献

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CHIR-98014 (CHIR98014, CHIR 98014)

生物&药学活性

物理化学性质&存储条件

参考文献

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