CHF6297 | p38α/β inhibitor | Probechem Biochemicals

Chemical Structure : CHF6297

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CHF6297 (CHF-6297, CHF 6297)

货号: PC-22072Not For Human Use, Lab Use Only.

CHF6297 (CHF-6297) is a potent and selective p38α/β MAPK inhibitor with IC50 of 0.14/0.2 nM, >1,000-fold selectivity against p38γ and p38δ.

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生物&药学活性

CHF6297 (CHF-6297) is a potent and selective p38α/β MAPK inhibitor with IC50 of 0.14/0.2 nM, >1,000-fold selectivity against p38γ and p38δ.
CHF6297 inhibits IL-8 release evoked by CSE in HBSMCs with IC50 of 0.79 nM.
CHF6297 dose-dependently counteractes the IL-1β (0.3 mg/kg)-induced neutrophil influx (ED50 = 0.22 mg/kg) and increase in IL-6 levels (ED50 = 0.82 mg/kg) in the BALF of rats.
CHF6297 (0.1 mg/kg, i.n.) significantly decreases airway neutrophilia in murine house dust mite (HDM) model of asthma exacerbated by influenza virus A (IAV) (H3N3).
CHF6297 effectively counteracteds lung inflammation in experimental models.

物理化学性质&存储条件

分子量	446.51
分子式	C24H26N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(((7-(2-aminopyrimidin-4-yl)-2,3-dihydrofuro[3,2-c]pyridin-4-yl)amino)methyl)-N-((tetrahydrofuran-2-yl)methyl)benzamide

参考文献

1. Cataldo Martucci, et al. Front Pharmacol. 2024 Mar 14:15:1343941.

CHF6297 (CHF-6297, CHF 6297)

生物&药学活性

物理化学性质&存储条件

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CHF6297 (CHF-6297, CHF 6297)

生物&药学活性

物理化学性质&存储条件

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