CHD4 inhibitor CH41

Chemical Structure : CHD4 inhibitor CH41

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货号: PC-27771Not For Human Use, Lab Use Only.

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生物&药学活性

CHD4 inhibitor CH41 is a potent small-molecule inhibitor of chromodomain helicase DNA-binding protein 4 (CHD4) with EC50 of 761 nM, recapitulates the effects of genetic CHD4 ablation on Treg function.
CH41 demonstrates dose-dependent cell target engagement with EC50 of 761 nM with full-length CHD4.
CH41 impaired intratumoral Treg accumulation and function and significantly inhibited the growth of lung and hepatocellular carcinomas in immunocompetent.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Xiong Y, et al. bioRxiv [Preprint]. 2026 Jul 31:2026.07.30.741771.