CHD1L inhibitor 6 |CAS:1251562-51-2 Probechem Biochemicals

Chemical Structure : CHD1L inhibitor 6

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CHD1L inhibitor 6

货号: PC-38167Not For Human Use, Lab Use Only.

CHD1L inhibitor 6 is the first-in-class small molecule inhibitor of oncogenic CHD1L with IC50 of 5.5 uM in cat-CHD1L ATPase assay.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

CHD1L inhibitor 6 is the first-in-class small molecule inhibitor of oncogenic CHD1L with IC50 of 5.5 uM in cat-CHD1L ATPase assay.
CHD1L effectively downregulated vimentin promoter activity with EC50 of 4.7 uM against CHD1L mediated TCF- transcription, reverse EMT and the malignant phenotype in CRC.
CHD1L inhibitor 6 is effective against patient-derived tumor organoids (PDTOs) with EC50 of 11.6 uM.
CHD1L inhibitor 6 displays good PK drug-like properties and the ability to alter EMT and induce apoptosis in vivo with no observed liver toxicity.

物理化学性质&存储条件

分子量	393.509
分子式	C21H23N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((6-methyl-2-(pyrrolidin-1-yl)pyrimidin-4-yl)amino)phenyl)-2-(thiophen-2-yl)acetamide

参考文献

1. Joshua M Abbott, et al. Mol Cancer Ther. 2020 Aug;19(8):1598-1612.