CHD1Li 6.11 | CHD1L inhibitor | Probechem Biochemicals

Chemical Structure : CHD1Li 6.11

CAS No.: 2716890-91-2

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CHD1Li 6.11 (CHD1L inhibitor, OTI-611)

货号: PC-72745Not For Human Use, Lab Use Only.

CHD1Li 6.11 (OTI-611) is a first in class, orally bioavailable oncogenic CHD1L inhibitor with 3.3 uM (CHD1L-cat enzyme activity).

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5 mg	￥1780	In stock
10 mg	￥2780	In stock
25 mg	￥4780	In stock
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100 mg		Get quote

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生物&药学活性

CHD1Li 6.11 (OTI-611) is a first in class, orally bioavailable oncogenic CHD1L inhibitor with 3.3 uM (CHD1L-cat enzyme activity).
CHD1Li 6.11 exhibits cytotoxicity with IC50 of 2.59 uM in SW620 parental tumor organoid.
CHD1Li 6.11 significantly reduced the tumor volume of CRC xenografts generated from isolated quasi mesenchymal cells (M-phenotype).
Chromodomain helicase DNA-binding protein 1 like (CHD1L) is an oncogene implicated in tumor progression, multidrug resistance, and metastasis in many types of cancer.

物理化学性质&存储条件

分子量	472.405
分子式	C21H22BrN5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-bromothiophen-2-yl)-N-(4-((6-methyl-2-(pyrrolidin-1-yl)pyrimidin-4-yl)amino)phenyl)acetamide

参考文献

1. Brett J Prigaro, et al. J Med Chem. 2022 Mar 10;65(5):3943-3961.

CHD1Li 6.11 (CHD1L inhibitor, OTI-611)

生物&药学活性

物理化学性质&存储条件

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CHD1Li 6.11 (CHD1L inhibitor, OTI-611)

生物&药学活性

物理化学性质&存储条件

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