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首页-小分子抑制剂&激动剂-GPCR-PTH Receptor-CH5447240
CH5447240

Chemical Structure : CH5447240

CAS No.: 1253919-92-4

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CH5447240 (CH-5447240)

货号: PC-35255Not For Human Use, Lab Use Only.

CH5447240 is a novel potent, selective, orally active hPTHR1 agonist with EC20 of 3.0 nM and EC50 of 12 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CH5447240 is a novel potent, selective, orally active hPTHR1 agonist with EC20 of 3.0 nM and EC50 of 12 nM.
    CH5447240 shows excellent physicochemical properties, such as high solubility in fasted state simulated intestinal fluid and good metabolic stability in human liver microsomes.
    CH5447240 demonstrates a significantly elevated serum calcium level in hypocalcemic model rats.

    物理化学性质&存储条件

    分子量 517.689
    分子式 C26H39N5O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(3,5-dimethyl-4-(2-((2-((1R,4R)-4-methylcyclohexyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-1-methylurea

    参考文献

    1. Nishimura Y, et al. J Med Chem. 2018 Jun 22. doi: 10.1021/acs.jmedchem.8b00182.

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