CH-3-8

Chemical Structure : CH-3-8

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货号: PC-49013Not For Human Use, Lab Use Only.

CH-3-8 is a novel microtubule polymerization inhibitor with little susceptible to transporter-mediated chemoresistance, binds to the colchicine-binding site in tubulin protein, disrupts microtubule dynamics at the nanomolar concentration in MIA PaCa-2 and PANC-1 pancreatic cancer cell lines.

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生物&药学活性

CH-3-8 is a novel microtubule polymerization inhibitor with little susceptible to transporter-mediated chemoresistance, binds to the colchicine-binding site in tubulin protein, disrupts microtubule dynamics at the nanomolar concentration in MIA PaCa-2 and PANC-1 pancreatic cancer cell lines.
CH-3-8 significantly inhibited the proliferation of these cells, induced G2/M cell cycle arrest, and led to apoptosis.
Systemic administration of CH-3-8 at the dose of 20 mg/kg into orthotopic pancreatic tumor-bearing NSG mice every alternate day resulted in significant tumor regression, without significant toxicity.

物理化学性质&存储条件

分子量	395.411
分子式	C22H21NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(6-(3-hydroxy-4-methoxyphenyl)pyridin-2-yl)(3,4,5-trimethoxyphenyl)methanone

参考文献

1. Rajan Sharma Bhattarai, et al. J Control Release. 2021 Jan 10;329:585-597.

CH-3-8

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CH-3-8

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物理化学性质&存储条件

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