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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Aryl hydrocarbon Receptor (AhR)-CH-223191
CH-223191

Chemical Structure : CH-223191

CAS No.: 301326-22-7

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CH-223191 (CH223191)

货号: PC-43148Not For Human Use, Lab Use Only.

CH-223191 is a potent, specific antagonist of AhR (aryl hydrocarbon receptor), potently inhibits TCDD-induced AhR-dependent transcription with IC50 of 0.03 uM.

规格 价格 库存 数量
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg ￥4280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CH-223191 (CH223191) is a potent, specific antagonist of AhR (aryl hydrocarbon receptor), potently inhibits TCDD-induced AhR-dependent transcription with IC50 of 0.03 uM.
CH-223191 shows more inhibitory potency and no agonist-like effect, compared with flavone, resveratrol, and α-naphthoflavone, as well as estrogenic potency.
CH-223191 inhibits TCDD-AhR binding and TCDD-induced nuclear translocation and DNA binding of AhR, prevents the expression of cytochrome P450 enzymes, target genes of the AhR.
CH-223191 potently prevents TCDD-elicited cytochrome P450 induction, liver toxicity, and wasting syndrome in mice

物理化学性质&存储条件

分子量 333.3871
分子式 C19H19N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 35 mg/mL
Chemical Name/SMILES

1H-Pyrazole-5-carboxamide, 1-methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]-

参考文献

1. Kim SH, et al. Mol Pharmacol. 2006 Jun;69(6):1871-8.

2. Veldhoen M, et al. J Exp Med. 2009 Jan 16;206(1):43-9.

3. Gramatzki D, et al. Oncogene. 2009 Jul 16;28(28):2593-605.

4. Shackleford G, et al. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1319-E1328.

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