CH-2-77 analogue 60c

Chemical Structure : CH-2-77 analogue 60c

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货号: PC-38804Not For Human Use, Lab Use Only.

CH-2-77 analogue 60c is a potent colchicine-binding site tubulin inhibitor, inhibits tubulin polymerization and is effective against P-glycoprotein-mediated multiple drug resistance and taxol resistance.

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100 mg		Get quote

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生物&药学活性

CH-2-77 analogue 60c is a potent colchicine-binding site tubulin inhibitor, inhibits tubulin polymerization and is effective against P-glycoprotein-mediated multiple drug resistance and taxol resistance.
CH-2-77 analogue 60c exhibited a strong inhibitory effect on tumor growth and metastasis in a taxol-resistant A375/TxR xenograft model without obvious toxicity.

物理化学性质&存储条件

分子量	397.402
分子式	C22H20FNO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-fluoro-6-(3-hydroxy-4-methylphenyl)pyridin-2-yl)(3,4,5-trimethoxyphenyl)methanone

参考文献

1. Hao Chen, et al. J Med Chem. 2021 Aug 26;64(16):12049-12074.