CH-2-77

Chemical Structure : CH-2-77

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货号: PC-38803Not For Human Use, Lab Use Only.

CH-2-77 is a potent colchicine-binding site inhibitor (CBSI) targeting tubulin, shows potent anti-proliferative activity against a panel of cancer cells in vitro and efficacious anti-tumor effects in vivo.

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100 mg		Get quote

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生物&药学活性

CH-2-77 is a potent colchicine-binding site inhibitor (CBSI) targeting tubulin, shows potent anti-proliferative activity against a panel of cancer cells in vitro and efficacious anti-tumor effects in vivo.
CH-2-77 inhibits the proliferation of both paclitaxel-sensitive and paclitaxel-resistant TNBC cells with an average IC50 of 3 nM.
CH-2-77 also efficiently disrupts the microtubule assembly, inhibits the migration and invasion of TNBC cells, and induces G2/M cell cycle arrest.
CH-2-77 shows acceptable overall pharmacokinetics and strongly suppresses the growth of orthotopic MDA-MB-231 xenografts without gross cumulative toxicities.
CH-2-77 prevents lung metastasis originating from the mammary fat pad in a dose-dependent manner.

物理化学性质&存储条件

分子量	379.412
分子式	C22H21NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(6-(3-hydroxy-4-methylphenyl)pyridin-2-yl)(3,4,5-trimethoxyphenyl)methanone

参考文献

1. Hao Chen, et al. J Med Chem. 2021 Aug 26;64(16):12049-12074.

CH-2-77

生物&药学活性

物理化学性质&存储条件

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CH-2-77

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物理化学性质&存储条件

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