CGX1321 | Probechem Biochemicals

Chemical Structure : CGX1321

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CGX1321 (CGX-1321)

货号: PC-38141Not For Human Use, Lab Use Only.

CGX1321 (CGX-1321) is a nove potent and specific inhibitor of porcupine (PORCN) that inhibits Wnt pathway, block secretion of WNT proteins with IC50 of 1 nM.

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生物&药学活性

CGX1321 (CGX-1321) is a nove potent and specific inhibitor of porcupine (PORCN) that inhibits Wnt pathway, block secretion of WNT proteins with IC50 of 1 nM.
CGX1321 displayed >500 times selective for Porcupine over the most related target enzyme, hedgehog acyltransferase
CGX1321 increased Ki67+ and phosphohistone H3 (PH3+) cardiomyocytes in culture, up-regulated cell cycle regulating genes such as Ccnb1 and Ccne1, did not alter YAP protein phosphorylation and nuclear translocation in cardiomyocytes.
CGX1321 administration blocked the secretion of Wnt proteins, and inhibited both canonical and non-canonical Wnt signaling pathways in MI injury mice.
CGX1321 improved cardiac function, reduced myocardial infarct size, and fibrosis of post-MI hearts.
CGX1321 significantly increased newly formed cardiomyocytes in infarct border zone of post-MI hearts, evidenced by the increased EdU+ cardiomyocytes.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 1 Month
Shipping
Solubility
Chemical Name/SMILES

参考文献

1. Yang D, et al. Clin Sci (Lond). 2017 Dec 8;131(24):2919-2932.

CGX1321 (CGX-1321)

生物&药学活性

物理化学性质&存储条件

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CGX1321 (CGX-1321)

生物&药学活性

物理化学性质&存储条件

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