CGS-15943 | Adenosine receptor inhibitor | Probechem Biochemicals

Chemical Structure : CGS-15943

CAS No.: 104615-18-1

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CGS-15943 (CGS 15943)

货号: PC-38488Not For Human Use, Lab Use Only.

CGS-15943 is a potent, non-xanthine adenosine receptor antagonist with Ki values of 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors respectively.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg	￥4280	In stock
250 mg		Get quote

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生物&药学活性

CGS-15943 is a potent, non-xanthine adenosine receptor antagonist with Ki values of 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors respectively.
CGS 15943 also inhibits the kinase activity of the class IB PI3K isoform p110γ with an IC50 of 1.1 μM and shows slight inhibition on p110δ with an IC50 of 8.47 μM.
CGS 15943 inhibits growth of HLF and SK-Hep-1 cells, as well as HepG2 and PLC-PRF-5 cells.
CGS 15943 reduces the phosphorylation of Akt at its residues Ser473 and Thr308 in SK-Hep-1 cells.

物理化学性质&存储条件

分子量	285.69
分子式	C13H8ClN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

参考文献

1. Williams M, et al. J Pharmacol Exp Ther. 1987 May;241(2):415-20.

2. Ghai G, et al. J Pharmacol Exp Ther. 1987 Sep;242(3):784-90.

3. Francis JE, et al. J Med Chem. 1988 May;31(5):1014-20.

4. Edling CE, et al. Cancer Biol Ther. 2014 May;15(5):524-32.

CGS-15943 (CGS 15943)

生物&药学活性

物理化学性质&存储条件

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CGS-15943 (CGS 15943)

生物&药学活性

物理化学性质&存储条件

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