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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-MNK-CGP57380
CGP57380

Chemical Structure : CGP57380

CAS No.: 522629-08-9

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CGP57380 (CGP 57380, CGP-57380)

货号: PC-42633Not For Human Use, Lab Use Only.

CGP57380 (CGP-57380) is a cell-permeable, specific MNK1 inhibitor with IC50 of 2.2 uM.

规格 价格 库存 数量
5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CGP57380 (CGP-57380) is a cell-permeable, specific MNK1 inhibitor with IC50 of 2.2 uM.
CGP57380 has no inhibitory activity on p38, JNK1, ERK1/2, etc.
CGP57380 inhibits phosphorylation of eIF4E in cellular assays with IC50 of 3 uM.

物理化学性质&存储条件

分子量 244.2278
分子式 C11H9FN6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 43 mg/mL
Chemical Name/SMILES

1H-Pyrazolo[3,4-d]pyrimidine-3,4-diamine, N3-(4-fluorophenyl)-

参考文献

1. Knauf U, et al. Mol Cell Biol. 2001 Aug;21(16):5500-11.

2. Wen Q, et al. Oncotarget. 2016 May 10;7(19):27787-801.

3. Lim S, et al. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2298-307.

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