CGP 37157 | NCX inhibitor | Probechem Biochemicals

Chemical Structure : CGP 37157

CAS No.: 75450-34-9

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CGP 37157 (CGP37157, CGP-37157)

货号: PC-61112Not For Human Use, Lab Use Only.

CGP37157 is a specific inhibitor of mitochondrial Na(+)-Ca(2+) exchanger (mNCE) with IC50 of 1.5 uM in INS-1 cells.

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10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg	￥3680	In stock
250 mg		Get quote

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生物&药学活性

CGP37157 is a specific inhibitor of mitochondrial Na(+)-Ca(2+) exchanger (mNCE) with IC50 of 1.5 uM in INS-1 cells.
CGP37157 decreases the amplitude of the mitochondrion-mediated plateau phase in cultured rat dorsal root ganglion neurons with IC50 of 4 uM.
CGP37157 increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets.

物理化学性质&存储条件

分子量	324.22
分子式	C15H11Cl2NOS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one

参考文献

1. Baron KT, et al. Eur J Pharmacol. 1997 Dec 11;340(2-3):295-300.

2. Lee B, et al. Diabetes. 2003 Apr;52(4):965-73.

3. Montero M, et al. Mol Biol Cell. 2001 Jan;12(1):63-71.

4. Visch HJ, et al. J Biol Chem. 2004 Sep 24;279(39):40328-36.

CGP 37157 (CGP37157, CGP-37157)

生物&药学活性

物理化学性质&存储条件

参考文献

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CGP 37157 (CGP37157, CGP-37157)

生物&药学活性

物理化学性质&存储条件

参考文献

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