CGP049090 |CAS:35082-49-6 Probechem Biochemicals

Chemical Structure : CGP049090

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CGP049090 (CGP 049090;Cercosporin)

货号: PC-61322Not For Human Use, Lab Use Only.

CGP049090 (Cercosporin) is a small-molecule that specifically inhibits the interaction of β-catenin/LEF1 transcriptional complex in colon carcinoma cell lines.

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生物&药学活性

CGP049090 (Cercosporin) is a small-molecule that specifically inhibits the interaction of β-catenin/LEF1 transcriptional complex in colon carcinoma cell lines.
CGP049090 efficiently kills CLL cells with LC50 of <1 uM, without significantly toxcity for normal B cells.
CGP049090 is well tolerated and exhibits tumor inhibition in in vivo studies.

物理化学性质&存储条件

分子量	534.517
分子式	C29H26O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6,12-dihydroxy-8,9-bis((R)-2-hydroxypropyl)-7,10-dimethoxyperyleno[1,12-def][1,3]dioxepine-5,11-dione

参考文献

1. Gandhirajan RK, et al. Neoplasia. 2010 Apr;12(4):326-35.

2. Minke KS, et al. Eur J Haematol. 2009 Mar;82(3):165-75.

3. Wei W, et al. Int J Cancer. 2010 May 15;126(10):2426-36.

CGP049090 (CGP 049090;Cercosporin)

生物&药学活性

物理化学性质&存储条件

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CGP049090 (CGP 049090;Cercosporin)

生物&药学活性

物理化学性质&存储条件

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