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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-CGP-74514A hydrochloride
CGP-74514A hydrochloride

Chemical Structure : CGP-74514A hydrochloride

CAS No.: 481724-82-7

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CGP-74514A hydrochloride (CGP74514A)

货号: PC-62821Not For Human Use, Lab Use Only.

CGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CGP-74514A hydrochloride is a potent CDK1 inhibitor with IC50 of 25 nM.
    CGP-74514A induces caspase-9 activation and PARP degradation, mediates apoptosis in U937 cells.
    CGP-74514A increases p21(CIP1) expression, p27(KIP1) degradation, diminished E2F1 expression, and dephosphorylation of p34(CDC2).

    物理化学性质&存储条件

    分子量 422.35
    分子式 C19H24ClN7 · HCl
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N2-((1S,2R)-2-aminocyclohexyl)-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine hydrochloride

    参考文献

    1. Dai Y, et al. Cell Cycle. 2002 Mar-Apr;1(2):143-52.

    2. Yu C, et al. Cancer Res. 2003 Apr 15;63(8):1822-33.

    3. Dai X, et al. Cell Cycle. 2012 Aug 15;11(16):3079-86.

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