CGK1026 |CAS:287383-59-9 Probechem Biochemicals

Chemical Structure : CGK1026

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CGK1026 (CGK-1026;CGK 1026)

货号: PC-70244Not For Human Use, Lab Use Only.

CGK1026 is a small molecule that inhibits human telomerase reverse transcriptase (hTERT) expression, inhibits HDAC activity with IC50 of 100 nM.

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生物&药学活性

CGK1026 is a small molecule that inhibits human telomerase reverse transcriptase (hTERT) expression, inhibits HDAC activity with IC50 of 100 nM.
CGK1026 inhibits the recruitment of HDAC into E2F-pocket protein complexes assembled on the hTERT promoter,.
CGK1026 induces G1 arrest of IMR90 cells.

物理化学性质&存储条件

分子量	326.352
分子式	C18H18N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide

参考文献

1. Won J, et al. Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11328-33.

2. Alimirah F, et al. Mol Cancer Res. 2007 Mar;5(3):251-9.

3. Song LL, et al. PLoS One. 2010 Jan 5;5(1):e8569.

CGK1026 (CGK-1026;CGK 1026)

生物&药学活性

物理化学性质&存储条件

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CGK1026 (CGK-1026;CGK 1026)

生物&药学活性

物理化学性质&存储条件

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