CFMB | FFAR2 agonist | Probechem Biochemicals

Chemical Structure : CFMB

CAS No.: 1208552-99-1

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CFMB (FFAR2 agonist 58)

货号: PC-72422Not For Human Use, Lab Use Only.

CFMB (FFAR2 agonist 58) is a potent, allosteric FFAR2 (GPR43) agonist / modulator with EC50 of 0.8 uM for hFFAR2 and 0.2 uM for rFFAR2.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

CFMB (FFAR2 agonist 58) is a potent, allosteric FFAR2 (GPR43) agonist / modulator with EC50 of 0.8 uM for hFFAR2 and 0.2 uM for rFFAR2.
CFMB functions as a positive/priming modulator in these cells by turning the natural FFA2R agonist acetate into a potent activator of the neutrophil NADPH-oxidase.
CFMB lowers the concentration of acetate required to induce a transient rise in the concentration of intracellular Ca2+ in neutrophils, has no direct effect on the neutrophil NADPH-oxidase activity but affects the response induced by acetate.
CFMB significantly reduced the amount of internalized influenza A virus (IAV) in treated A549 cells.

物理化学性质&存储条件

分子量	384.922
分子式	C21H21ClN2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility
Chemical Name/SMILES	(S)-2-(4-chlorophenyl)-3,3-dimethyl-N-(5-phenylthiazol-2-yl)butanamide

参考文献

1. Jonas Mårtensson, et al. J Leukoc Biol. 2018 Dec;104(6):1117-1132.

2. Guangwen Wang, et al. J Virol. 2020 Jan 6;94(2):e01707-19.

CFMB (FFAR2 agonist 58)

生物&药学活性

物理化学性质&存储条件

参考文献

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CFMB (FFAR2 agonist 58)

生物&药学活性

物理化学性质&存储条件

参考文献

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