CFM-4.16 | CARP-1 inducer | Probechem Biochemicals

Chemical Structure : CFM-4.16

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CFM-4.16 (CFM4.16)

货号: PC-35499Not For Human Use, Lab Use Only.

CFM-4.16 is a CARP-1 functional mimetic (CFM) compound bind with CARP-1, stimulates CARP-1 expression and apoptosis.

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生物&药学活性

CFM-4.16 is a CARP-1 functional mimetic (CFM) compound binding with CARP-1, stimulates CARP-1 expression and apoptosis.
CFM-4.16 attenuates the activation of STAT3, a transducer of signaling following activation of the EGFR and Src TKs.
CFM-4.16 robustly inhibits oncogenic intracellular kinase Akt activity and/or expression in wild-type HCC 827, H1975 and H23 NSCLC cells.
CFM-4.16 also inhibited Akt activation in erlotinib and gemcitabine-resistant, but not in osimertinib-resistant, NSCLC cells.
CFM-4.16 causes superior inhibition of viability of TNBC cells when used in combination with doxorubicin.

物理化学性质&存储条件

分子量	440.342
分子式	C22H15Cl2N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-chlorobenzyl)-5'-(3-chlorophenyl)-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one

参考文献

1. Cheriyan VT, et al. Oncotarget. 2018 Jul 3;9(51):29680-29697.

2. Cheriyan VT, et al. Oncotarget. 2016 Nov 8;7(45):73370-73388.

CFM-4.16 (CFM4.16)

生物&药学活性

物理化学性质&存储条件

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CFM-4.16 (CFM4.16)

生物&药学活性

物理化学性质&存储条件

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