CFI-401980 |CAS:1610676-27-1 Probechem Biochemicals

Chemical Structure : CFI-401980

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CFI-401980 (CFI401980)

货号: PC-62727Not For Human Use, Lab Use Only.

CFI-401980 is a potent, selective, novel class TTK (Tyrosine Threonine Kinase, MPS1) inhibitor with Ki of 0.8 nM, HCT116 GI50 of 13 nM.

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生物&药学活性

CFI-401980 is a potent, selective, novel class TTK (Tyrosine Threonine Kinase, MPS1) inhibitor with Ki of 0.8 nM, HCT116 GI50 of 13 nM.
CFI-401980 shows exceptional kinase selectivity; demonstrate a strong anti-proliferative activity in a panel of human cancer cell lines (HCT116 GI50<15 nM) and good rodent pharmacokinetics (oral %F 97%).

物理化学性质&存储条件

分子量	498.587
分子式	C28H30N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-cyclopropyl-2-methyl-4-(2-phenoxy-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide

参考文献

1. Laufer R, et al. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3562-6.

CFI-401980 (CFI401980)

生物&药学活性

物理化学性质&存储条件

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CFI-401980 (CFI401980)

生物&药学活性

物理化学性质&存储条件

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