CES1 inhibitor DL-9

Chemical Structure : CES1 inhibitor DL-9

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货号: PC-26683Not For Human Use, Lab Use Only.

CES1 inhibitor DL-9 is a slow-binding allosteric inhibitor of Carboxylesterase 1 (CES1) with IC50 of 45.36 uM, Cys 390 is critical for the inhibition of CES1 by DL-9.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

CES1 inhibitor DL-9 is a slow-binding allosteric inhibitor of Carboxylesterase 1 (CES1) with IC50 of 45.36 uM, Cys 390 is critical for the inhibition of CES1 by DL-9.
DL-9 (50 uM) resulted in a significant reduction in human CES1 activity relative to vehicle control (mean inhibition 73%).
CES1 inhibitor DL-9 effectively reduce apolipoprotein B 100 (APOB) secretion in iPSC-derived hepatocyte.

物理化学性质&存储条件

分子量	364.53
分子式	C17H24N4OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,6-di-tert-butyl-4-((4,6-dimercapto-1,3,5-triazin-2-yl)amino)phenol

参考文献

1. Blaszkiewicz J, et al. Cell Mol Gastroenterol Hepatol. 2026 Apr 28:101796.

2. Jui-Tung Liu, et al. Commun Biol. 2023 Apr 24;6(1):452.