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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Mixed Lineage Kinase (MLK)-CEP1347
CEP1347

Chemical Structure : CEP1347

CAS No.: 156177-65-0

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CEP1347 (KT-7515, KT7515, CEP-1347)

货号: PC-70174Not For Human Use, Lab Use Only.

CEP1347 (KT7515) is a potent and selective mixed lineage kinase (MLK) inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM.

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1 mg ￥5880 In stock
5 mg ￥9880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CEP1347 (KT7515) is a potent and selective mixed lineage kinase (MLK) inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM.
CEP1347 has weak inhibitory activity for Trk A and MLCK.
CEP1347 promotes motoneuron survival and simultaneously inhibits the JNK1 signaling cascade.
CEP1347 inhibits recombinant MLK1/2/3 with IC50 of 23-51 nM; blocks cell death (overexpression of MLK3) in CHO cells.
CEP1347 elicits neuroprotective and anti-inflammatory responses in models of neurodegenerative diseases.

物理化学性质&存储条件

分子量 615.76
分子式 C33H33N3O5S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

methyl (5R,7R,8S)-2,11-bis((ethylthio)methyl)-7-hydroxy-15-oxo-5,6,7,8,14,15-hexahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-7-carboxylate

参考文献

1. Kaneko M, et al. J Med Chem. 1997 Jun 6;40(12):1863-9.

2. Maroney AC, et al. J Neurosci. 1998 Jan 1;18(1):104-11.

3. Maroney AC, et al. J Biol Chem. 2001 Jul 6;276(27):25302-8.

4. Eggert D, et al. J Immunol. 2010 Jan 15;184(2):746-56.

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