CEP-7055 | VEGFR inhibitor | Probechem Biochemicals

Chemical Structure : CEP-7055

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CEP-7055 (CEP7055)

货号: PC-63493Not For Human Use, Lab Use Only.

CEP-7055 is a potent, orally active, pan inhibitor of VEGFR, CEP-7055 is the dimethylglycine ester prodrug of CEP-5214, which inhibits human VEGFR2/KDR kinase, VEGFR1/FLT-1 kinase, and VEGFR3/FLT-4 kinase with IC50 of 18 nM, 12 nM, and 17 nM.

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生物&药学活性

CEP-7055 is a potent, orally active, pan inhibitor of VEGFR, CEP-7055 is the dimethylglycine ester prodrug of CEP-5214, which inhibits human VEGFR2/KDR kinase, VEGFR1/FLT-1 kinase, and VEGFR3/FLT-4 kinase with IC50 of 18 nM, 12 nM, and 17 nM.
CEP-7055 demonstrates significant in vivo antitumor activity in numerous tumor models.

物理化学性质&存储条件

分子量	525.64
分子式	C32H35N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Glycine, N,N-dimethyl-, 3-[5,6,7,13-tetrahydro-9-[(1-methylethoxy)methyl]-5-oxo-12H-indeno[2,1-a]pyrrolo[3,4-c]carbazol-12-yl]propyl ester

参考文献

1. Ruggeri B, et al. Cancer Res. 2003 Sep 15;63(18):5978-91.

2. Gingrich DE, et al. J Med Chem. 2003 Dec 4;46(25):5375-88.

3. Jones-Bolin S, et al. Mol Cancer Ther. 2006 Jul;5(7):1744-53.

CEP-7055 (CEP7055)

生物&药学活性

物理化学性质&存储条件

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CEP-7055 (CEP7055)

生物&药学活性

物理化学性质&存储条件

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