CEP-33779 | JAK2 inhibitor | Probechem Biochemicals

Chemical Structure : CEP-33779

CAS No.: 1257704-57-6

加入收藏

CEP-33779 (CEP33779)

货号: PC-21900Not For Human Use, Lab Use Only.

CEP-33779 is a potent, selective, and orally bioavailable inhibitor of JAK2 with IC50 of 1.3 nM, 65-fold selective over JAK-3.

规格	价格	库存
10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥2880	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CEP-33779 is a potent, selective, and orally bioavailable inhibitor of JAK2 with IC50 of 1.3 nM, 65-fold selective over JAK-3.
CEP-33779 decreases NF-κB activation modulating the proinflammatory tumor microenvironment.
CEP-33779 impacts neoplasia by restricting tumor cell proliferation and angiogenesis.
CEP-33779 strongly suppresses growth of established tumors in an AOM/DSS–induced model of colorectal cancer.
CEP-33779 mitigates several immune parameters associated with SLE advancement, including the protection and treatment of mice with lupus nephritis.

物理化学性质&存储条件

分子量	462.57
分子式	C24H26N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(4-Methylpiperazin-1-yl)phenyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

参考文献

1. Seavey MM, et al. Mol Cancer Ther. 2012 Apr;11(4):984-93.

2. Lu LD, et al. J Immunol. 2011 Oct 1;187(7):3840-53.

CEP-33779 (CEP33779)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

CEP-33779 (CEP33779)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.