CELF1-IN-27 | CELF1 inhibitor | Probechem Biochemicals

Chemical Structure : CELF1-IN-27

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CELF1-IN-27 (Compound 27)

货号: PC-72933Not For Human Use, Lab Use Only.

CELF1-IN-27 is a selective CUGBP Elav-like family member 1 (CELF1) inhibitor that disrupted CELF1-RNA binding with IC50 of 23 uM, targets RRM1/2 of CELF1.

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生物&药学活性

CELF1-IN-27 is a selective CUGBP Elav-like family member 1 (CELF1) inhibitor that disrupted CELF1-RNA binding with IC50 of 23 uM, targets RRM1/2 of CELF1.
CELF1-IN-27 promotes IFN-γ secretion and suppresses TGF-β1-induced hepatic stellate cell (HSC) activation by inhibiting CELF1-mediated IFN-γ mRNA decay, the upregulated antifibrogenic IFN-γ inhibits HSC activation.
CELF1-IN-2 7attenuates CCl4-induced murine liver fibrosis in vivo.

物理化学性质&存储条件

分子量	187.246
分子式	C11H13N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N3,N3-dimethylisoquinoline-1,3-diamine

参考文献

1. Yang Tan, et al. Nucleic Acids Res. 2022 Mar 2;gkac139.

CELF1-IN-27 (Compound 27)

生物&药学活性

物理化学性质&存储条件

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CELF1-IN-27 (Compound 27)

生物&药学活性

物理化学性质&存储条件

参考文献

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