CE-224535 |CAS:724424-43-5 Probechem Biochemicals

Chemical Structure : CE-224535

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CE-224535 (CE224535;PF-04905428)

货号: PC-61575Not For Human Use, Lab Use Only.

CE-224535 (PF-04905428) is a potent and selective P2X7 receptor antagonist with IC50 of 1.4 nM (inhibition of the release of lL-1b from monocytes stimulated by ATP).

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生物&药学活性

CE-224535 (PF-04905428) is a potent and selective P2X7 receptor antagonist with IC50 of 1.4 nM (inhibition of the release of lL-1b from monocytes stimulated by ATP).
CE-224535 demonstrates potential antiinflammatory action in various conditions such as arthritis, allergies, asthma, COPD, autoimmune diseases and other disorders.

物理化学性质&存储条件

分子量	480.946
分子式	C22H29ClN4O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Chloro-N-[(1-hydroxycycloheptyl)methyl]-5-[4-[(2R)-2-hydroxy-3-methoxypropyl]-3,5-dioxo-1,2,4-triazin-2-yl]benzamide

参考文献

1. Duplantier AJ, et al. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3708-11.

2. Stock TC, et al. J Rheumatol. 2012 Apr;39(4):720-7.

CE-224535 (CE224535;PF-04905428)

生物&药学活性

物理化学性质&存储条件

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CE-224535 (CE224535;PF-04905428)

生物&药学活性

物理化学性质&存储条件

参考文献

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