CDRI-1709S

Chemical Structure : CDRI-1709S

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货号: PC-27859Not For Human Use, Lab Use Only.

CDRI-1709S is a highly potent, selective small molecule AdipoR1 (Adiponectin receptor 1) with EC50 of 414.7 pM, activates adiponectin signalling via AdipoR1 but not AdipoR2.

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生物&药学活性

CDRI-1709S is a highly potent, selective small molecule AdipoR1 (Adiponectin receptor 1) agonist with EC50 of 414.7 pM, activates adiponectin signalling via AdipoR1 but not AdipoR2.
CDRI‐1709S promoted C2C12 myoblast differentiation into mature myotubes, accompanied by increased expression of MyoD and myogenin.
CDRI‐1709S also reverses Dexamethasone‐mediated impairments in oxidative and glycolytic capacity.
CDRI‐1709S activated hallmark adiponectin‐associated signalling events, including phosphorylation of AMPK, AKT and p38‐MAPK, in AdipoR1‐overexpressing HEK293T and AdipoR‐rich C2C12 myotubes.
CDRI‐1709S protected myotubes against Dexamethasone, LPS + TNFα and PBS (nutrient deficiency)‐induced atrophy.
CDRI‐1709S prevented dexamethasone‐induced skeletal muscle atrophy in SD rats.

物理化学性质&存储条件

分子量	262.24
分子式	C15H11NaO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium 6a,11a-dihydro-6H-benzofuro[3,2-c]chromen-3-olate

参考文献

1. Md Rameez Moin, et al. J Cachexia Sarcopenia Muscle. 2026 Aug;17(4):e70328.

CDRI-1709S

生物&药学活性

物理化学性质&存储条件

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CDRI-1709S

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物理化学性质&存储条件

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