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首页-小分子抑制剂&激动剂-GPCR-mGluR-CDPPB
CDPPB

Chemical Structure : CDPPB

CAS No.: 781652-57-1

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CDPPB (CD-PPB)

货号: PC-62955Not For Human Use, Lab Use Only.

CDPPB is a potent, selective, brain penetrant positive allosteric modulator of mGlu5 receptor with EC50 of 10 nM and 20 nM for human and rat mGluR5, respectively.

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5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CDPPB is a potent, selective, brain penetrant positive allosteric modulator of mGlu5 receptor with EC50 of 10 nM and 20 nM for human and rat mGluR5, respectively.
CDPPB reverses amphetamine-induced locomotor activity and amphetamine-induced deficits in prepulse inhibition in rats.

物理化学性质&存储条件

分子量 364.408
分子式 C23H16N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide

参考文献

1. Kinney GG, et al. J Pharmacol Exp Ther. 2005 Apr;313(1):199-206.

2. Chen Y, et al. Mol Pharmacol. 2007 May;71(5):1389-98.

3. Lindsley CW, et al. J Med Chem. 2004 Nov 18;47(24):5825-8.

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