CDP-840 hydrochloride | Probechem Biochemicals

Chemical Structure : CDP-840 hydrochloride

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CDP-840 hydrochloride (CDP840;L-765527;GR259653X)

货号: PC-63097Not For Human Use, Lab Use Only.

CDP-840 (CDP840.

规格	价格	库存	数量
100 mg		Get quote
250 mg		Get quote
500 mg		Get quote
1 g		Get quote

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生物&药学活性

CDP-840 (CDP840;L-765527) hydrochloride is a potent and selective PDE4 inhibitor with IC50 of 4-45 nM for PDE4 extracted from tissues or recombinant PDE 4 isoforms expressed in yeast.

CDP-840 shows no effect for PDE-1, 2, 3, 5, and 7 (IC50>100 uM), exhibits no significant selectivity in inhibiting human recombinant isoenzymes PDE-4A, B, C or D and is equally active against the isoenzymes lacking UCR1 (PDE-4B2 and PDE-4D2).

CDP-840 causes a dose-dependent reduction of IL-5-induced pleural eosinophilia in rats (ED50=0.03 mg/kg).

CDP-840 prevents antigen-induced eosinophilia and bronchoconstriction; orally active.

物理化学性质&存储条件

分子量	409.95
分子式	C25H27NO2.HCl
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[(2R)-2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-pyridine hydrochloride

参考文献

1. Hughes B, et al. Br J Pharmacol. 1996 Jul;118(5):1183-91.

2. Holbrook M, et al. Br J Pharmacol. 1996 Jul;118(5):1192-200.

3. Perry MJ, et al. Cell Biochem Biophys. 1998;29(1-2):113-32.

CDP-840 hydrochloride (CDP840;L-765527;GR259653X)

生物&药学活性

物理化学性质&存储条件

参考文献

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CDP-840 hydrochloride (CDP840;L-765527;GR259653X)

生物&药学活性

物理化学性质&存储条件

参考文献

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