CDNB

Chemical Structure : CDNB

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货号: PC-23929Not For Human Use, Lab Use Only.

CDNB is a selective small molecule inhibitor of thioredoxin reductase (TrxR), inhibits TrxR activity with IC50 of 9.4 uM in raw macrophages.

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生物&药学活性

CDNB is a selective small molecule inhibitor of thioredoxin reductase (TrxR), inhibits TrxR activity with IC50 of 9.4 uM in raw macrophages.
CDNB causes apoptosis without depletion of glutathione or loss of mitochondrial complex I-activity in neuronal cell lines.
CDNB displays an early increase of reactive oxygen species and rapid activation of stress inducible protein kinases c-Jun N-terminal kinase (JNK) and mitogen activated protein kinase kinase 4 (MKK4).
CDNB induces reactive oxygen species and subsequent activation of stress-inducible kinases without impairment of the cellular antioxidant status or mitochondrial function.

物理化学性质&存储条件

分子量	202.55
分子式	C6H3ClN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-chloro-2,4-dinitrobenzene

参考文献

1. Heiss E, et al. Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1601-11.

2. Kang HJ, et al. Mol Cells. 2006 Aug 31;22(1):113-8.

3. Seyfried J, et al. Biochem Biophys Res Commun. 2007 Aug 3;359(3):759-64.

CDNB

生物&药学活性

物理化学性质&存储条件

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CDNB

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