CDN1163 |CAS:892711-75-0 Probechem Biochemicals

Chemical Structure : CDN1163

CAS No.: 892711-75-0

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CDN1163 (CDN 1163;CDN-1163)

货号: PC-35299Not For Human Use, Lab Use Only.

CDN1163 (CDN-1163) is a small molecule, allosteric activator of SERCA2, dose-dependently increases the Vmax of SERCA2 Ca2+-ATPase activity in ER microsomes.

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10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥3180	In stock
100 mg		Get quote

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生物&药学活性

CDN1163 (CDN-1163) is a small molecule, allosteric activator of SERCA2, dose-dependently increases the Vmax of SERCA2 Ca2+-ATPase activity in ER microsomes.
CDN1163 increases Ca2+-ATPase activity and significantly enhances Ca2+ uptake into the ER, attenuates H2O2-stimulated cell death in HEK cells.
CDN1163 improves glucose homeostasis and metabolic parameters, increases glucose tolerance in ob/ob mice.
CDN1163 reduces lipid accumulation and decreases lipogenesis in obese mice livers.

物理化学性质&存储条件

分子量	320.392
分子式	C20H20N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide

参考文献

1. Krajnak K, et al. Bioorg Med Chem Lett. 2018 May 15;28(9):1591-1594.

2. Kang S, et al. J Biol Chem. 2016 Mar 4;291(10):5185-98.

3. Dahl R. Bioorg Med Chem. 2017 Jan 1;25(1):53-57.

4. Cornea RL, et al. J Biomol Screen. 2013 Jan;18(1):97-107.

CDN1163 (CDN 1163;CDN-1163)

生物&药学活性

物理化学性质&存储条件

参考文献

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CDN1163 (CDN 1163;CDN-1163)

生物&药学活性

物理化学性质&存储条件

参考文献

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