CDKL2 inhibitor 9

Chemical Structure : CDKL2 inhibitor 9

加入收藏

货号: PC-22396Not For Human Use, Lab Use Only.

CDKL2 inhibitor 9 is a selective cyclin-dependent kinase-like 2 (CDKL2, KKIAMRE, P56) chemical probe inhibitor with enzyme IC50 of 230 nM in radiometric enzymatic assays.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CDKL2 inhibitor 9 is a selective cyclin-dependent kinase-like 2 (CDKL2, KKIAMRE, P56) chemical probe inhibitor with enzyme IC50 of 230 nM in radiometric enzymatic assays.
CDKL2 inhibitor 9 exhibits IC50 of 460 nM in the CDKL2 NanoBRET assay to gauge their ability to engage CDKL2 in cells.
CDKL2 inhibitor 9 displays excellent kinome-wide selectivity against 403 wild-type human kinases with selectivity score (S10(1 µM) = 0.002), as well as high selectivity over CDKL1, CDKL3, CDKL4, or CDKL5.
CDKL2 inhibitor 9 suppressed the CDKL2-mediated EB2 phosphorylation in a dose-dependent manner in rat primary neurons.

物理化学性质&存储条件

分子量	426.54
分子式	C22H26N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-(3-(((2-methylpropyl)sulfonamido)methyl)phenyl)-1H-indazol-3-yl)cyclopropanecarboxamide

参考文献

1. Bashore FM, et al. bioRxiv [Preprint]. 2024 May 14:2024.05.12.593776.