CDK7 and 9 inhibitor 14 |CAS:851439-14-0 Probechem Biochemicals

Chemical Structure : CDK7 and 9 inhibitor 14

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CDK7 and 9 inhibitor 14 (CDK7/9-IN-14)

货号: PC-61180Not For Human Use, Lab Use Only.

CDK7/9-IN-14 is a potent, selective transcriptional CDK inhibitor with Ki of 2.3 and 0.38 nM for CDK7 and CDK9, respectively.

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生物&药学活性

CDK7/9-IN-14 is a potent, selective transcriptional CDK inhibitor with Ki of 2.3 and 0.38 nM for CDK7 and CDK9, respectively.
CDK7/9-IN-14 displays >30-fold selectivity over CDK1/2/4, inhibits VEGFR2 with IC50 of 180 nM in a panel of non-CDK kinases.
CDK7/9-IN-14 demonstrates a broad spectrum of in vitro antitumor activity with average IC50 of 0.3 uM with no selectivity toward cell line types based on p53, p21, p16, or pRb status.
CDK7/9-IN-14 significantly reduces phosphorylation of both Ser-2 and Ser-5 of the RNAP-II CTD, reduces antiapoptotic protein levels in cells, and selectively induces apoptosis in transformed cells.
CDK7/9-IN-14 demonstrates antitumor activity in murine xenograft solid tumor models.

物理化学性质&存储条件

分子量	382.486
分子式	C19H22N6OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,4-dimethyl-5-[2-(4-piperazin-1-yl-phenylamino)-pyrimidin-4-yl]-3H-thiazol-2-one

参考文献

1. Wang S, et al. Chem Biol. 2010 Oct 29;17(10):1111-21.

CDK7 and 9 inhibitor 14 (CDK7/9-IN-14)

生物&药学活性

物理化学性质&存储条件

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CDK7 and 9 inhibitor 14 (CDK7/9-IN-14)

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物理化学性质&存储条件

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