CDK5 inhibitor 20-223 |CAS:865317-30-2 Probechem Biochemicals

Chemical Structure : CDK5 inhibitor 20-223

CAS No.: 865317-30-2

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CDK5 inhibitor 20-223 (CP 668863)

货号: PC-62573Not For Human Use, Lab Use Only.

CDK5 inhibitor 20-223 (CP 668863) potent, selective, ATP-competitive CDK2/5 inhibitor with IC50 of 6.0 and 8.8 nM for CDK2/CyclinE and CDK5/p35, with little to no activity against CDK1/4/6/7/9.

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4580	In stock
100 mg		Get quote

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生物&药学活性

CDK5 inhibitor 20-223 (CP 668863) potent, selective, ATP-competitive CDK2/5 inhibitor with IC50 of 6.0 and 8.8 nM for CDK2/CyclinE and CDK5/p35, with little to no activity against CDK1/4/6/7/9.
CDK5 inhibitor 20-223 decreases pRB (S807/811) and pFAK (S732) levels in CRC cell lines, effectively blocks the kinase activity of CDK2 and CDK5 in multiple CRC cell lines.
CDK5 inhibitor 20-223 reduces migration of CRC cells, reduces cell growth in a panel of human CRC cell lines with mean IC50 of 362 nM.
CDK5 inhibitor 20-223 effectively slows tumor progression in mice models.

物理化学性质&存储条件

分子量	305.381
分子式	C19H19N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-cyclobutyl-1H-pyrazol-5-yl)-2-(naphthalen-2-yl)acetamide

参考文献

1. Robb CM, et al. Oncotarget. 2017 Dec 28;9(4):5216-5232.

CDK5 inhibitor 20-223 (CP 668863)

生物&药学活性

物理化学性质&存储条件

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CDK5 inhibitor 20-223 (CP 668863)

生物&药学活性

物理化学性质&存储条件

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