CDK17 inhibitor DU12

Chemical Structure : CDK17 inhibitor DU12

加入收藏

货号: PC-26877Not For Human Use, Lab Use Only.

DU12 is a potent small molecule CDK17 inhibitor with IC50 of 0.76 uM against recombinant CDK17 kinase, inhibits the proliferation, colony formation, migration, and invasion of SKOV3 and A2780 ovarian cancer cells with IC50 of 2.83 uM and 2.65 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

DU12 is a potent small molecule CDK17 inhibitor with IC50 of 0.76 uM against recombinant CDK17 kinase, inhibits the proliferation, colony formation, migration, and invasion of SKOV3 and A2780 ovarian cancer cells with IC50 of 2.83 uM and 2.65 uM.
DU12 significantly suppressed tumor growth and downregulated the expression of CDK17, SEMA6C, and PLXNA2 in tumor tissues.
DU12 downregulates the SEMA6C-Plexin A2 signaling pathway by targeting CDK17.
CDK17 promotes SEMA6C protein stability by suppressing its ubiquitin-dependent degradation.
DU12 markedly inhibits ovarian cancer growth in vivo and downregulates the CDK17-SEMA6C axis.

物理化学性质&存储条件

分子量	538.55
分子式	C32H26O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-hydroxy-2-(4-methoxy-3-(2-phenylacetoxy)phenyl)-4-oxochroman-7-yl 2-phenylacetate

参考文献

1. Pan C, et al. Biochem Pharmacol. 2026 May 15:118069.