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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-CDK12-IN-3
CDK12-IN-3

Chemical Structure : CDK12-IN-3

CAS No.: 2220184-50-7

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CDK12-IN-3

货号: PC-28041Not For Human Use, Lab Use Only.

CDK12-IN-3 is a potent, selective, noncovalent CDK12 inhibitor with IC50 of 491 nM, inhibits phosphorylation of Ser2 on the C-terminal repeat domain of RNA polymerase II.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CDK12-IN-3 is a potent, selective, noncovalent CDK12 inhibitor with IC50 of 491 nM, inhibits phosphorylation of Ser2 on the C-terminal repeat domain of RNA polymerase II.

物理化学性质&存储条件

分子量 470.53
分子式 C23H28F2N8O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

[(S)-2-(1-(6-(((6,7-difluoro-1H-benzo[d]imidazol-2-yl)methyl)amino)-9-isopropyl-9H-purin-2-yl)piperidin-2-yl)ethan-1-ol]

参考文献

1. Johannes JW, et al. ChemMedChem. 2018 Feb 6;13(3):231-235.

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