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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Alkylator/Crosslinker-CDEAH
CDEAH

Chemical Structure : CDEAH

CAS No.: 869-24-9

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CDEAH

货号: PC-21025Not For Human Use, Lab Use Only.

CDEAH is a monofunctional alkylating agent that selectively kills PARP1- and xeroderma pigmentosum A-deficient cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CDEAH is a monofunctional alkylating agent that selectively kills PARP1- and xeroderma pigmentosum A-deficient cells.
    CDEAH preferentially alkylates guanine nucleobases, forming DNA adducts that can be removed from DNA by either a PARP1-dependent base excision repair or nucleotide excision repair.
    CDEAH treatment leads to the formation of strand breaks, an accumulation of cells in S phase and activation of the DNA damage response.
    CDEAH selectively inhibits PARP1-deficient xenograft tumor growth compared to isogenic PARP1-proficient tumors.

    物理化学性质&存储条件

    分子量 172.09
    分子式 C6H15Cl2N
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-chloro-N,N-diethylethanamine hydrochloride

    参考文献

    1. Minwoo Wie, et al. NAR Cancer. 2023 Aug 7;5(3):zcad042.

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