CDDO-TFEA | Nrf2 activator | Probechem Biochemicals

Chemical Structure : CDDO-TFEA

CAS No.: 932730-52-4

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CDDO-TFEA (CDDO-Trifluoethyl amide, RTA 404, TP-500)

货号: PC-25215Not For Human Use, Lab Use Only.

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5 mg	￥2880	In stock
10 mg	￥4780	In stock
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生物&药学活性

CDDO-TFEA (RTA 404, TP-500) is a trifluoroacetamide derivative of CDDO with enhanced ability to cross the blood-brain barrier, an Nrf2 activator that inhibits proliferation and induces differentiation and apoptosis in various cancer cells.
CDDO-TFEA induces apoptosis and blocks colony formation in Ewing's sarcoma and neuroblastoma cell lines with IC50 values ranging from 85-170 nM.
CDDO-TFEA can enhance Nrf2 expression and signaling in various neurodegenerative disease models, including those mimicking multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease.

物理化学性质&存储条件

分子量	572.71
分子式	C33H43F3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-N-(2,2,2-trifluoroethyl)-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicene-4a(2H)-carboxamide

参考文献

1. Stack, et al. Free Radic. Biol. Med. 49(2), 147-158 (2010).

2. Borbala Daroczi, et al. Mol Cancer Ther. 2009 Sep;8(9):2625-34.

CDDO-TFEA (CDDO-Trifluoethyl amide, RTA 404, TP-500)

生物&药学活性

物理化学性质&存储条件

参考文献

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CDDO-TFEA (CDDO-Trifluoethyl amide, RTA 404, TP-500)

生物&药学活性

物理化学性质&存储条件

参考文献

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