CDDO-Im | PPAR agonist, Nrf2 activator | Probechem Biochemicals

Chemical Structure : CDDO-Im

CAS No.: 443104-02-7

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CDDO-Im (RTA-403, TP-235, CDDO-Imidazolide)

货号: PC-44663Not For Human Use, Lab Use Only.

CDDO-Im (RTA-403) is a potent Nrf2 activator that elevates protein levels of Nrf2 and induces Nrf2/ARE signaling, also activates PPAR with Ki values of 232 and 344 nM for PPARα and PPARγ.

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1 mg (Free Sample)	￥280	In stock
10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥2980	In stock
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生物&药学活性

CDDO-Im (RTA-403) is a potent Nrf2 activator that elevates protein levels of Nrf2 and induces Nrf2/ARE signaling, also activates PPAR with Ki values of 232 and 344 nM for PPARα and PPARγ.
CDDO-Im induced Ahr, Cyp1a1, and Cyp1b1 transcription in Nrf2+/+ MEFs but not in Nrf2-/- MEFs.
CDDO-Im significantly reduces lung oxidative stress, alveolar cell apoptosis, alveolar destruction, and pulmonary hypertension in Nrf2(+/+) mice.

物理化学性质&存储条件

分子量	541.7235
分子式	C34H43N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Imidazole, 1-(2-cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-

参考文献

1. Liby K, et al. Cancer Res. 2005 Jun 1;65(11):4789-98.

2. Sussan TE, et al. Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):250-5.

3. Shin S, et al. Mol Cell Biol. 2007 Oct;27(20):7188-97.

CDDO-Im (RTA-403, TP-235, CDDO-Imidazolide)

生物&药学活性

物理化学性质&存储条件

参考文献

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CDDO-Im (RTA-403, TP-235, CDDO-Imidazolide)

生物&药学活性

物理化学性质&存储条件

参考文献

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