CDD-3167 | Ephrin receptor inhibitor | Probechem Biochemicals

Chemical Structure : CDD-3167

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CDD-3167 (CDD3167)

货号: PC-22283Not For Human Use, Lab Use Only.

CDD-3167 (CDD3167) is a potent, selective pan-ephrin receptor kinase (EPH receptor) inhibitor with binding Ki of 0.13/0.38 nM, cell IC50 of 8.0/2.3 nM for EPHA2/EPHA4, respectively.

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生物&药学活性

CDD-3167 (CDD3167) is a potent, selective pan-ephrin receptor kinase (EPH receptor) inhibitor with binding Ki of 0.13/0.38 nM, cell IC50 of 8.0/2.3 nM for EPHA2/EPHA4, respectively.
CDD-3167 significantly decreases EFNA5 (ligand) induced phosphorylation of EPHA2/4, decreases 12Z cell viability, and decreases IL-1β-mediated expression of prostaglandin synthase 2 (PTGS2) in 12Z endometriotic epithelial cells.
CDD-3167 decreases expansion of primary endometrial epithelial organoids from patients with endometriosis and decreases Ewing's sarcoma viability.

物理化学性质&存储条件

分子量	458.56
分子式	C27H30N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(5-hydroxy-2-methylphenyl)-6-methyl-N-(2-(4-(methylcarbamoyl)piperidin-1-yl)phenyl)picolinamide

参考文献

1. Madasu C, et al. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2322934121.

CDD-3167 (CDD3167)

生物&药学活性

物理化学性质&存储条件

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CDD-3167 (CDD3167)

生物&药学活性

物理化学性质&存储条件

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