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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Ephrin Receptor-CDD-3167
CDD-3167

Chemical Structure : CDD-3167

CAS No.:

CDD-3167 (CDD3167)

货号: PC-22283Not For Human Use, Lab Use Only.

CDD-3167 (CDD3167) is a potent, selective pan-ephrin receptor kinase (EPH receptor) inhibitor with binding Ki of 0.13/0.38 nM, cell IC50 of 8.0/2.3 nM for EPHA2/EPHA4, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CDD-3167 (CDD3167) is a potent, selective pan-ephrin receptor kinase (EPH receptor) inhibitor with binding Ki of 0.13/0.38 nM, cell IC50 of 8.0/2.3 nM for EPHA2/EPHA4, respectively.
    CDD-3167 significantly decreases EFNA5 (ligand) induced phosphorylation of EPHA2/4, decreases 12Z cell viability, and decreases IL-1β-mediated expression of prostaglandin synthase 2 (PTGS2) in 12Z endometriotic epithelial cells.
    CDD-3167 decreases expansion of primary endometrial epithelial organoids from patients with endometriosis and decreases Ewing's sarcoma viability.

    物理化学性质&存储条件

    分子量 458.56
    分子式 C27H30N4O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-(5-hydroxy-2-methylphenyl)-6-methyl-N-(2-(4-(methylcarbamoyl)piperidin-1-yl)phenyl)picolinamide

    参考文献

    1. Madasu C, et al. Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2322934121.

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